Association Mapping in Structured Populations

Association mapping in structured populations.

The use, in association studies, of the forthcoming dense genomewide collection of single-nucleotide polymorphisms (SNPs) has been heralded as a potential breakthrough in the study of the genetic basis of common complex disorders. A serious problem with association mapping is that population structure can lead to spurious associations between a candidate marker and a phenotype. One common solut...

Association mapping in plant populations

QTL Mapping II: Outbred Populations and Association Mapping Mapping in Outbred Populations

Ancestry specific association mapping in admixed populations

Genetic association studies have during the last decade proven to be a powerful approach to identifying disease-causing variants. However, many populations, like the Greenlandic Inuit population, have recently experienced substantial admixture with other populations, which can complicate association studies. One important complication is that most current methods for performing association test...

Mapping in structured populations by resample model averaging.

Highly recombinant populations derived from inbred lines, such as advanced intercross lines and heterogeneous stocks, can be used to map loci far more accurately than is possible with standard intercrosses. However, the varying degrees of relatedness that exist between individuals complicate analysis, potentially leading to many false positive signals. We describe a method to deal with these pr...